Establishment of a miniature pig model of mandibular osteoradionecrosis.
- Author:
Song LI
;
Dianji FANG
;
Zhanyi WANG
;
Lulu ZHAI
;
Zhaorong NING
;
Yanwei GUO
- Publication Type:Journal Article
- MeSH: Animals; Mandible; Mandibular Diseases; pathology; Molar; Osteoradionecrosis; pathology; Particle Accelerators; Radiation Injuries, Experimental; pathology; Radiotherapy, Conformal; adverse effects; Swine; Swine, Miniature; Tooth Extraction
- From: West China Journal of Stomatology 2015;33(6):570-574
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a miniature pig model of mandibular osteoradionecrosis (ORN).
METHODSA single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination.
RESULTSAt 3-4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group.
CONCLUSIONA miniature pig model of mandibular ORN can be established through 25 Gy irradiation + dental extraction.