Estrogen Receptor Gene PvuII and XbaI Polymorphism in Patients with Endometriosis.
- Author:
Young Min CHOI
1
;
Seung Yup KU
;
Kyu Ri HWANG
;
Yong Tack LIM
;
Sung Hyo PARK
;
Jong Kwan JUN
;
Noh Hyun PARK
;
In Ae PARK
;
Chang Suk SUH
;
Seok Hyun KIM
;
Jung Gu KIM
;
Shin Yong MOON
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Endometriosis;
Estrogen receptor gene;
Polymorphism;
PvuII;
XbaI
- MeSH:
Alleles;
Endometriosis*;
Estrogens*;
Female;
Humans;
Laparoscopy;
Laparotomy
- From:Korean Journal of Obstetrics and Gynecology
2003;46(8):1531-1536
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To explore the association of the estrogen receptor PvuII and XbaI polymorphism with endometriosis. METHODS: One hundred sixty women with surgically or histologically diagnosed endometriosis of stages I-IV, and 142 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Frequency and distribution of PvuII and XbaI polymorphisms for estrogen receptor gene were evaluated. RESULTS: There was no statistically significant difference in the allele distribution of PvuII polymorphism between the patients and the controls (pp of 35%, pP of 51%, PP of 14% vs. 42%, 44%, 15%, p>0.1); or in the frequency of the positive PvuII allele (0.61 vs. 0.63, p>0.1). And no significant difference was also observed in the allele distribution of XbaI polymorphism between the patients and the controls (xx of 66%, xX of 29%, XX of 5% vs. 68%, 30%, 1%, p>0.1); or in the frequency of the positive XbaI allele (0.80 vs. 0.83, p>0.1). CONCLUSION: These results suggest that the PvuII or XbaI polymorphism of the estrogen receptor gene is not associated with the risk for endometriosis in the Korean population.
