Predict value of time to peak of systolic velocity derived from velocity vector imaging on cardiac resynchronization therapy response in refractory heart failure patients
10.3760/cma.j.issn.0253-3758.2015.09.013
- VernacularTitle:速度向量成像技术在预测心脏再同步化治疗效果中的作用
- Author:
Jianping GUO
1
;
Yutang WANG
;
Guang ZHI
;
Xiaojuan ZHANG
;
Zhaoliang SHAN
;
Xiangmin SHI
;
Kun LIN
Author Information
1. 解放军总医院心血管内科
- Keywords:
Heart failure,congestive;
Pacemaker artificial;
Ultrasonography
- From:
Chinese Journal of Cardiology
2015;43(9):806-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of cardiac resynchronization therapy (CRT) on left ventricular systolic function evaluated by velocity vector imaging (VVI) in refractory heart failure patients and the predictive value of VVI on CRT responses.Methods This study included 38 patients with medically refractory heart failure (HF) patients underwent CRT in our department from May 2007 to April 2011.Left ventricular long axis dyssynchrony indexes including time to peak of systolic velocity (Ts max-min),standard deviation of the time to peak of systolic velocity (Ts-SD) before and at 3-6 months post CRT.CRT response was defined as 15％ decrease in left ventricular end-systolic volume.ROC curve and the area under the curve (AUC) were calculated.Results Twenty-four patients were defined as responder.No significant difference was observed between responders and non-responders in medical therapy.When using Ts max-min to predict response,the AUC of ROC curves was 0.76 ± 0.07.The sensitivity and specifity was 70.8％ and 77.8％ respectively with Ts max-min≥124.0 ms.When using Ts-SD to predict response,the AUC of ROC curves was 0.82 ±0.07.The sensitivity and specifity was 79.2％ and 71.2％ respectively with Ts-SD≥40.5.Conclusion Ts-SD is a useful index to predict CRT response in refractory HF patients.
