Impact of statin therapy on recurrence of persistent atrial fibrillation after electrical cardioversion:a meta-analysis
10.3760/cma.j.issn.0253-3758.2015.11.014
- VernacularTitle:他汀类药物对持续性心房颤动电复律后复发影响的荟萃分析
- Author:
Qian YANG
1
;
Xiaoyong QI
;
Yi DANG
;
Xuelian SONG
;
Xiao HAO
Author Information
1. 河北省人民医院心脏中心
- Keywords:
Atrial fibrillation;
Antilipemic agents;
Meta-analysis
- From:
Chinese Journal of Cardiology
2015;43(11):994-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of statin therapy on the recurrence rate in patients with persistent atrial fibrillation (AF) after electrical cardioversion.Methods PubMed,EMBbase,Cochrane central register of controlled trials were searched up to February 2015 to identify randomized controlled trials,which reported the effect of statin therapy on AF recurrence after electrical cardioversion.The data were analyzed by RevMan 5.3 and Stata 12.0 software.Results Six trials with 572 patients were included.The result showed that statin therapy had no effect on the recurrence rate in patients with persistent AF after electrical cardioversion (OR=0.60,95％CI:0.32-1.11,P＞0.05) compared with controls.Four out of the six trials investigated the effect of atorvastatin on the recurrence rate of AF after electrical cardioversion,subgroup analysis of these trials showed that compared with controls,atorvastatin had no effect on the recurrence of AF after electrical cardioversion (OR=0.59,95％CI:0.25-1.39,P＞0.05).Three out of the six trials had high quality (Jadad score≥3),subgroup analysis of these trials also showed that statins did not affect the recurrence rate of AF after electrical cardioversion (OR=0.76,95％CI:0.49-1.16,P＞0.05).Conclusion This analysis suggested that statin therapy had no effect on the recurrence rate in patients with persistent AF after electrical cardioversion.
