Expression of Matrix Metalloproteinase (MMP)-2, MMP-9, Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2 in Adenocarcinomas of The Gallbladder.
- Author:
Jong Yup BAE
1
;
Jinsub CHOI
;
Hyun Cheol CHUNG
;
Chanil PARK
;
Young Nyun PARK
Author Information
1. Department of Pathology, Kumi CHA Hospital, College of Medicine, Pochon CHA University, Kumi, Korea.
- Publication Type:Original Article
- Keywords:
Gallbladder Neoplasms;
Matrix Metalloproteinases;
Tissue Inhibitor of Metalloproteinases;
Immunohistochemistry
- MeSH:
Adenocarcinoma*;
Collagen Type IV;
Connective Tissue;
Gallbladder Neoplasms;
Gallbladder*;
Immunohistochemistry;
Lymph Nodes;
Matrix Metalloproteinases;
Neoplasm Metastasis;
Serous Membrane;
Tissue Inhibitor of Metalloproteinase-1;
Tissue Inhibitor of Metalloproteinase-2*;
Tissue Inhibitor of Metalloproteinases
- From:Korean Journal of Pathology
2003;37(1):1-9
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Matrix metalloproteinase (MMP)-2 and MMP-9 degrade type IV collagen and are antagonized by the tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-1, respectively. METHODS: We studied by immunohistochemistry the expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 in 72 cases of adenocarcinoma of the gallbladder. RESULTS: The MMP-2, MMP-9 and TIMP-1 expressions were significantly higher in well/moderately differentiated adenocarcinomas than in poorly differentiated adenocarcinomas, in adenocarcinomas that had invaded the lamina propria/proper muscle than in those that had invaded the perimuscular connective tissue or beyond the serosa, and in adenocarcinomas with fungating growth than in those with infiltrative growth. The TIMP-2 expression showed a similar pattern without statistical significance. Regarding the status of lymph node metastasis, the MMP-2 expression was significantly higher in cases without lymph node metastasis. The MMP-2 and MMP-9 expressions were significantly related to those of TIMP-2 and TIMP-1, respectively, with regard to depth of invasion, differentiation, and growth patterns of the adenocarcinomas. CONCLUSIONS: MMP-2, MMP-9, TIMP-1 and TIMP-2 are suggested to play important roles in the progression to early invasion of adenocarcinomas, in which the function of MMP-2 is inhibited by TIMP-2.
