Effects of mechanical ventilation on plasma IL-6, IL-10 and TNF-alpha in children after cardiopulmonary bypass.
- Author:
Peng HUANG
1
;
Wen-Wu ZHOU
;
Ping-Bo LIU
Author Information
- Publication Type:Journal Article
- MeSH: Cardiopulmonary Bypass; Female; Humans; Infant; Interleukin-10; blood; Interleukin-6; blood; Male; Respiration, Artificial; Tumor Necrosis Factor-alpha
- From: Chinese Journal of Contemporary Pediatrics 2008;10(6):708-710
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of different models of mechanical ventilation on inflammatory cytokines, IL-6, IL-10 and TNF-alpha, in children after cardiopulmonary bypass (CPB).
METHODSSixty patients who underwent CPB were randomly divided into group A and group B. After CPB, group A was ventilated with high tidal volume (VT, 10-12 mL/kg) /low positive end-expiratory pressure (PEEP, 3-5 cm H2O), while group B was ventilated with low VT (6-8 mL/kg) /high PEEP (6-9 cm H2O). Plasma levels of IL-6, IL-10 and TNF-alpha were measured before operation, at the end of the operation, and 1 and 6 hrs after operation.
RESULTSSerum levels of IL-6, IL-10 and TNF-alpha in both groups increased significantly at the end of the operation and reached a peak by 1 hr after operation. Group B showed lower serum levels of IL-6, IL-10 and TNF-alpha than group A 1 and 6 hrs after operation.
CONCLUSIONSMechanical ventilation with low VT /high PEEP may more effectively inhibit the release of inflammatory cytokines than that with high VT /low PEEP in children after CPB.
