Effect of endemic fluorosis on children's intelligence development: a Meta analysis.
- Author:
Ming LIU
1
;
Cong QIAN
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child Development; Fluorosis, Dental; psychology; Humans; Intelligence
- From: Chinese Journal of Contemporary Pediatrics 2008;10(6):723-725
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of high levels of fluoride on children's intelligence development by analyzing the literatures systematically.
METHODSThe literatures on the relationship between endemic fluorosis and children's intelligence development published between 1995 and 2007 were retrieved electronically and manually. A total of 13 relevant literatures that met the inclusion criteria were included for Meta analysis. Meta analysis was performed using the Coorporative network software RevMan 4.3.
RESULTSThe subjects of the 13 literatures included 2 508 children from the high fluoride group and 2 330 children from the control group. Meta analysis showed these literatures were inhomogenous (x2=268.05, p<0.01). Therefore a random effect model was used. The average effect scale (OR=-7.14; 95%CI: -9.90, -4.37) suggested a negative correlation between high fluorosis exposure and children's intelligence development.
CONCLUSIONSExposure to high levels of fluoride may adversely influence children's intelligence development.
