Roles of serum and urinary interleukins 13Ralpha2 and other cytokines in pediatric Henoch-Schonlein purpura.
- Author:
Yan-Hong YU
1
;
Kai-Li PAN
;
Qi LI
;
Bao-Juan ZHANG
;
Ying HUANG
;
Jing-Jing ZHANG
;
Li DU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Cytokines; physiology; Female; Humans; Interleukin-13 Receptor alpha2 Subunit; blood; physiology; Interleukin-6; physiology; Male; Purpura, Schoenlein-Henoch; etiology; immunology; Tumor Necrosis Factor-alpha; physiology
- From: Chinese Journal of Contemporary Pediatrics 2009;11(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the roles of serum and urinary interleukins (IL)-13Ralpha2, IL-4, IL-6, IL-8 and tumor necrosis factor-alpha(TNF-alpha) in pediatric Henoch-Schonlein purpura (HSP).
METHODSSerum and urinary levels of IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha were examined using ELISA in 52 children with HSP and 45 healthy children. The results were compared between the two groups.
RESULTSSerum levels of IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha in HSP patients with or without renal lesions were higher than those in the control group (p<0.01 or 0.05). Urinary levels of IL-6 and TNF-alpha in HSP patients without renal lesions were higher than those in the control group (p<0.05). Except for urinary levels of IL-6 and TNF-alpha, urinary IL-13Ralpha2 levels in HSP patients with renal lesions (HSPN) were higher than those in the control group (p<0.05).
CONCLUSIONSCytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN.
