Study on the position of genes responsible for gallstone disease in Chinese population.
- Author:
Jian QIN
1
;
Tian-quan HAN
;
Wen-tao YUAN
;
Jian FEI
;
Zhi-hong JIANG
;
Jing ZHANG
;
Yi WANG
;
Wei HUANG
;
Sheng-dao ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Age Factors; Asian Continental Ancestry Group; Body Mass Index; Cholecystolithiasis; ethnology; genetics; Chromosomes, Human, Pair 11; genetics; Chromosomes, Human, Pair 3; genetics; Chromosomes, Human, Pair 4; genetics; Chromosomes, Human, Pair 9; genetics; Female; Genetic Linkage; Genetic Predisposition to Disease; Humans; Male; Microsatellite Repeats; Pedigree
- From: Chinese Journal of Surgery 2006;44(7):485-487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo search the susceptibility genes of gallstone disease in Chinese population.
METHODSA genome wide scan was performed in twelve families with gallstone disease using fluorescence-labeled microsatellite markers. Genehunter and Batchlink of Linkage package were used for non- parameter and parameter linkage analysis to search the linkage loci on chromosomes.
RESULTSFour loci of D3S1266, D4S406, D9S1682 and D11S902 showed suggestive evidence for linkage. nonparametric linkage analysis (NPL)-score of D4S406 and D9S1682 was 1.77 (P = 0.05) and 1.92 (P = 0.04) respectively. The corresponding logarithm of the odds ratio (LOD)-score of D3S1266, D9S1682 were 1.35 and 2.07, and showed a rise of LOD-score from 1.35 to 2.71, 2.07 to 2.40 respectively when families with later-found patients or with higher triglyceride level were analyzed alone. Transmitted disequilibrium test of D11S902 showed a P-value of 0.0027.
CONCLUSIONSChromosome 3, 4, 9 and 11 may contain genes involved in gallstone disease in Chinese population, and chromosome 3, 9 may hide genes that are liked to gallstone disease in families with later-found patients or with higher triglyceride concentration.