A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin".
10.1016/S2095-4964(16)60242-X
- Author:
Mahsa JALILI
1
;
Zahra BAZI
2
;
Azita HEKMATDOOST
1
Author Information
1. Clinical Nutrition Department, Nutrition Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2. Medical Biotechnology Department, Medicine Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Publication Type:Journal Article
- MeSH:
Fibronectins;
genetics;
Furin;
genetics;
Genetic Therapy;
Humans;
Obesity;
therapy;
Pichia;
genetics;
Recombinant Fusion Proteins;
genetics;
Transferrin;
genetics;
Weight Loss
- From:
Journal of Integrative Medicine
2016;14(1):1-4
- CountryChina
- Language:English
-
Abstract:
Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
