The detection and clinical significance of hepatic fibrosis index

VernacularTitle:肝纤维化指标的检测及临床意义
Author: Chun-Hai XU ¹ ; Dong-Mei MENG ; Shu-Lan LV ; Peng KANG
Author Information

1. 哈尔滨医科大学第二附属医院
Keywords: Hepatitis B chronic; Fibrosis; Hyaluronic acid; Laminin; Liver cirrhosis; Collagen Type Ⅳ; Procollagen Type Ⅲ
From: Chinese Journal of Experimental and Clinical Virology 2010;24(1):50-52
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between levels of serum HA, LN, Ⅳ-C,PC Ⅲ of chronic hepatitis and indexes of hepatic fibrosis. Methods The levels of serum HA,LN, Ⅳ-C and PC Ⅲ of chronic hepatitis of 124 cases and health 18 cases were measured by radio immunoassay, combined with clinical characteristics and 33 cases pathologic slice etc. The diagnostic of the indexes of serum was analyzed with statistics. Results HA and Ⅳ-C are parallel in chronic hepatitis periods. LN and PC Ⅲ are concert in the same pathologic periods. In G_4 period PC Ⅲ is nearly closed with comparative group. The value of HA, LN, Ⅳ-C and PC Ⅲ in the chronic hepatitis group was significantly higher than that in the normal comparative group. Conclusion The levels of serum HA LN Ⅳ-C and PC Ⅲ are in concert with the degree of hepatic fibrosis, and these indexes are valuable for chronic hepatitis diagnoses combined with the clinic. LN and PC Ⅲ are coincidence with hepatic fibrosis degree before G_4 period.