The study of the sensitive and specificity on HBV DNA replication by HBV-lP detecting.
- Author:
Ping-Nan SHAN
1
;
Zhi-Yong LU
;
Guo-Hong XUAN
;
Li-Min WENG
;
Jin-Cheng RU
;
Su-Hong TAN
;
De-Shun XU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; DNA Replication; Enzyme-Linked Immunosorbent Assay; methods; Hepatitis B; blood; diagnosis; virology; Hepatitis B virus; genetics; isolation & purification; Humans; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; methods; Sensitivity and Specificity; Viral Envelope Proteins; blood; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2010;24(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect HBV-LP and HBV DNA of the patients with hepatitis B, and to study the sensitive and specificity of HBV-LP detecting and its evaluate on for clinical application.
METHODSThe ELISA was used for HBV-LP detecting and RT-PCR for HBV DNA detecting.
RESULTSThe sensitive and specificity of HBV-LP and HBV DNA were 64.89%, 99.68%, 60.63% and 100% respectively (P > 0.05); +LR, -LR were 202.78, 60.63, 0.3522 and 0.3937, and there were significance between +LR of the detecting (P < 0.005).
CONCLUSIONThe sensitive and specificity of HBV-LP and HBV DNA detecting are considerable, +LR of HBV-LP are higher comparing HBV DNA. The HBV-LP is better serology index for detecting replication of HBV DNA.
