The study of the sensitive and specificity on HBV DNA replication by HBV-LP detecting

VernacularTitle:HBV-LP检测HBV DNA复制的敏感性与特异性研究
Author: Ping-Nan SHAN ¹ ; Zhi-Yong LU ; Guo-Hong XUAN ; Li-Min WENG ; Jin-Cheng RU ; Su-Hong TAN ; De-Shun XU
Author Information

1. 浙江,绍兴县中心医院暨中国医大绍兴医院
Keywords: Hepatitis B surface antigens; Hepaitis B virus; DNA; Sensitivity and Specificity
From: Chinese Journal of Experimental and Clinical Virology 2010;24(1):68-70
CountryChina
Language:Chinese
Abstract: Objective To detect HBV-LP and HBV DNA of the patients with hepatitis B, and to study the sensitive and specificity of HBV-LP detecting and its evaluate on for clinical application. Methods The ELISA was used for HBV-LP detecting and RT-PCR for HBV DNA detecting. Results The sensitive and specificity of HBV-LP and HBV DNA were 64.89% ,99.68% ,60.63% and 100% respectively(P > 0.05);+LR, -LR were 202.78,60.63, 0.3522 and 0.3937, and there were significance between +LR of the detecting (P<0.005 ). Conclusion The sensitive and specificity of HBV-LP and HBV DNA detecting are considerable, +LRof HBV-LP are higher comparing HBV DNA. The HBV-LP is better serology index for detecting replication of HBV DNA.