Molecular epidemiology investigation of rabies virus nucleoprotein genes in China

VernacularTitle:中国狂犬病N基因分子流行病学调查研究
Author: Hao LI ¹ ; Xiao-Yan TAO ; Xiao-Guang WANG ; Yong-Liang LEI ; Hai-Lin ZHANG ; Xian-Jun WANG ; Shu-Jun DING ; Hong ZHANG ; De-Fang DAI ; Rui-Hua SHEN ; Qing TANG
Author Information

1. 中国疾病预防控制中心
Keywords: Rabies virus; Genetics,biochemical; Genes; Variation (genetic); Disease outbreaks
From: Chinese Journal of Experimental and Clinical Virology 2010;24(2):82-84
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between the distribution of rabies virus and genetic variation,the genetic characterization and variation of rabies virus strains in China were analyzed.Methods The downstream 720 nucleotides of Nucleoprotein (N) gene coding region of the rabies specimens from different areas and host animals were sequenced,and then homology and phylogenesis were analyzed.Results Nucleotide similarities of 34 N gene sequences were 87.5%-100%,and the deduced amino acid similarities were 93.3%-99.6%.Most of the nucleotide variations were synonymous mutations.Conclusion The 34 rabies specimens all belong to genotype Ⅰ and are of regional characteristic.The rabies viruses in high-incidence areas in China are of various origins and present the transmission tendency from high-incidence areas to surrounding regions.There may be cross-infection and mutual spread of rabies virus between wildlife and domestic animals as well as native and foreign animals.