Association of activated CD4+ cell and HBeAg with liver damage and cirrosis in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2010.02.017
- VernacularTitle:活化Th细胞及HBeAg与慢性乙肝肝损伤及纤维化关系的探讨
- Author:
Ping-Yang SHAO
1
;
Ren-Ye DING
Author Information
1. 浙江省嘉兴市第二医院
- Keywords:
Hepatitis B,chronic;
CD4-positive T-lymphocytes;
Hepatitis B e antigens;
A3 partate aminotransferases;
Alanine transaminase
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of the CD4~+ cell counts and HBeAg with liver damage and cirrosis in patients with chronic hepatitis B(CHB).Method To measure the lymphocytes both CD4 and HLA-DR positive of 58 patients with CHB and 18 patients with HBsAg negative but HBcAb positive.The Platelets(PLT) were counted and the ALT and AST were measured,meanwhile,AST/PLT values were calculated.Results The CD4~+ cell counts of the three types patients were lower than those of healthy controls significantly,and those of HBcAb positive patients without CHB were higher than those of HBeAg negative patients with CHB which were higher than those of HBeAg positive patients significantly(P＜0.05).And the ALT,AST and AST/PLT levels of both HBeAg negative and positive patients were much higher than the three indicators of both HBeAb positive patients without CHB and healthy controls significantly(P＜0.02),meanwhile,the three indicators of HBeAg negative patients were much lower than those of HBeAg positive ones.In addition,the CD4~+ cell counts of the two types patients were negatively correlative with the three indicators(P＜0.05).Conclusion Decreased CD4~+ cell count can be used as the indicator to predicate the progress of liver damage in patients with CHB,and it is also useful for HBeAg to evaluate the development degree of liver damage and fibrosis in CHB patients.
