Efficacy and safety of ademetionine for treatment of drug-induced Hver disease in children
10.3760/cma.j.issn.1003-9279.2010.02.020
- VernacularTitle:腺苷蛋氨酸治疗儿童药物性肝病的疗效及安全性的临床研究
- Author:
Shi-Shu ZHU
1
;
Yi DONG
;
Yu GAN
;
Hong-Mei TANG
;
Zhi-Qiang XU
;
Da-Wei CHEN
;
Wen-Zheng JIA
;
Li-Min WANG
;
Hong-Fei ZHANG
Author Information
1. 解放军第302医院
- Keywords:
Child,hospitalized;
Liver diseases/Drug effects;
S-Adenosylmethionine
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(2):136-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of ademetionine for treatment of cholestatic or mixed-type drug-induced liver disease (DILD) in children.Methods The children with DILD were divided into the treated group and control group.Yinzhihuang Granule was orally administered and Compound Glycyrrhizin Injection intravenously given in patients of both groups.Those patients in the treated group were additionally treated with intravenous infusion of 250-1000 mg ademetionine for 28 d.The incidence of pruritus and adverse effects as well as biochemical parameters in all the patients and compared between the 2 groups.For statistical analysis,X~2 test was used for between-group comparison and t test for processing the data.Results 1) Before treatment,severe pruritus was found in 17 and 16 children in the treated and control group,respectively.Two weeks after the treatment,the symptom was significantly relieved in 14 and 3 patients in the treated and control group,respectively (X~2= 4.52,P＜0.05).2) As for comparisons between the 2 groups,a P value of 0.0014 for AST level was found 4 weeks,0.045 and 0.007 for disappearance and recovery rate of jaundice,0.0014 and 0.0006 for decrease in TBA level and 0.0003 for γGT level 2 and 4 weeks after the treatment.Conclusion Intravenous administration of ademetionine is safe in children with DILD and it can effectively alleviate pruritus,promote the recovery of various biochemical parameters and fasten liver functional recovery in these children.Therefore,ademetionine can be widely used for treatment of intrahepatic cholestasis in children.
