The virological response in prolonged therapy of chronic hepatitis C with low-dose peginterferon alpha-2a
10.3760/cma.j.issn.1003-9279.2010.02.023
- VernacularTitle:PEG-IFN α-2a治疗慢性丙型肝炎的临床分析
- Author:
Jun-Ying ZHOU
1
;
Dong-Fang ZHOU
;
Wen-Li XING
;
Cai-Yan ZHAO
;
Zhen ZHEN
Author Information
1. 河北医科大学第三医院
- Keywords:
Hepatitis C,chronic;
Interferon Alfa-2a;
Ribavirin;
Polyethylene glycols
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(2):142-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the virological response in prolonged therapy of chronic hepatitis C (CHC) with low-dose peginterferon alpha-2a.Methods The 92 cases of in-patients with chronic hepatitis C in September 2004 to September 2006 were divided to three groups according the endurance of interferon.The dose of peginterferon alpha-2a was 67.5 μg,90 μg and 180 μg per week in group A,B and C respectively.The treatment duration of peginterferon alpha-2a was 96 or 48 weeks in HCV genotype 1b and 2a in group A and B,and in the group C the duration was 48 or 24 weeks in genotype 1b and 2a patients respectively.Meanwhile,ribavirin for 900-1200 mg per day combined treated with all patients.The quantitation of serum HCV RNA were conducted to determine the rapid virological response (RVR),early virological response (EVR) and sustained virological response (SVR) respectively.Results There were no significant difference between the three groups in the rate of RVR,EVR and SVR(P＞0.05).There was a higer rate of RVR,EVR and SVR in the genotype 2a group than the genotype 1b group (P＜0.05).HCV genotype was the independent predictor(OR=12.78.95%,CI=11.97-82.89,P=0.0075) of SVR.Conclusion There was a similar virological response between prolonged therapy of chronic hepatitis C with low-dose peginterferon alpha-2a and the standard dose and duration.The genotype was the independent predictors of SVR in peginterferon alpha-2a antiviral therapy of chronic hepatitis C.
