Study on the changes of the T-lymphocyte subsets and their significance in influenza A (H1N1) virus patients.
- Author:
Song-Ping ZHANG
1
;
Ming-Li ZHU
;
Jian-Hua YU
;
Ying WANG
;
Guo-Qiang LOU
Author Information
- Publication Type:Journal Article
- MeSH: CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; immunology; CD8 Antigens; CD8-Positive T-Lymphocytes; immunology; Cell Communication; immunology; Flow Cytometry; HLA-DR Antigens; Humans; Influenza A Virus, H1N1 Subtype; pathogenicity; Influenza A virus; Influenza Vaccines; immunology; Influenza, Human; immunology; pathology; Lymphocyte Activation; immunology; Lymphocyte Count; T-Lymphocyte Subsets; cytology; pathology; T-Lymphocytes; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2010;24(3):181-183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of T-Lymphocyte and activated T-Lymphocyte subsets in influenza A (H1N1) virus patients.
METHODSThe percentages of the subsets of Lymphocyte were detected by flow cytometry in influenza A (H1N1) virus patients (n = 144) and normal controls (n = 41). Furthermore, the subsets of T-Lymphocyte and activated T-lymphocyte were analyzed in 83 among those patients before and after treatment.
RESULTSCompared with the control group, the counts of Lymphocyte in patients with influenza A (H1N1) virus was significantly discreased, the counts of Lymphocyte in patients with influenza A virus concurrent pneumonia was significantly discreased those of no concurrent pneumonia; Compared with the control group, the percentage of T-lymphocyte in patients with influenza A virus concurrent pneumonia was significantly discreased. The counts and percentage of CD3 and CD8 cells was significantly discreased in patients (n = 83) before treatment; The counts of CD4 cells was significantly discreased before treatment. The percentage of HLA-DR+ CD+, HLA-DR+ CD4+ and HLA-DR+ CD8+ cells was significantly discreased in patients (n = 83) before treatment.
CONCLUSIONSTo understand the expression of the T-Lymphocyte and activated T-Lymphocyte subsets in influenza A (H1N1) virus patients may help to evaluate the patients' cellular immune status, but also be a guideline of early diagnosis of Influenza A (H1N1) virus.
