Study on the relationship between HBV viral loads and the changes of liver pathological features in patients with HBeAg-negative chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2010.03.008
- VernacularTitle:HBeAg阴性慢性乙型肝炎患者血清病毒载量与肝组织学改变的关系
- Author:
Chuan-Tong LU
1
;
Wen-Hong ZHOU
;
Ai-Rong HU
Author Information
1. 宁波市传染病医院
- Keywords:
Hepatitis B,chronic;
Hepaitis B e antigens;
DNA;
Hepatitis viruses;
Histopathology
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(3):184-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum HBV DNA loads and liver histology damage in the patients with HBeAg-negative chronic hepatitis B.Methods The retrospective study was performed.The 514 patients were divided into two groups according to the HBeAg status and the HBeAg positive group was as control.The relationship among HBV DNA loads,live histological inflammation grades and fibrosis stages was analyzed.Results The HBV DNA loads in HBeAg-negative group and HBeAg-positive group were(5.38±1.27)log10 copies/ml and(6.80±1.18)log10 copies/ml respectively(P<0.001).The inflammation grades and fibrosis stages of liver tissues in HBeAg-negative group were all significantly higher than those in HBeAg-positive group(P<0.001).In HBeAg-negative group,HBV DNA loads displayed a positive correlation with the inflammation grades and fibrosis stages of liver tissues(P<0.001).Conclusion In the patients with HBeAg-negative chronic hepatitis B,HBV viral loads are lower than those with HBeAg-positive chronic hepatitis B,and HBV viral loads display a positive correlation with liver the inflammation grades and fibrosis stages of liver tissues.
