Lamivudine and entecavir significantly improved the prognosis of early-to-mid stage hepatitis B related acute on chronic liver failure
10.3760/cma.j.issn.1003-9279.2010.03.015
- VernacularTitle:核苷类似物治疗早中期HBV-ACLF患者随机对照临床研究
- Author:
Jin-Hua HU
1
;
Hui-Fen WANG
;
Wei-Ping HE
;
Xiao-Yan LIU
;
Ning DU
;
Kun HUANG
;
Jin-Biao DING
;
Xue-Zhang DUAN
;
Jing CHEN
;
Ju-Mei CHEN
Author Information
1. 解放军第302医院
- Keywords:
Liver failure;
Hepatitis B;
Nueleosides;
Antiviral therapy;
Randomized controlled trials
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clinically study the antiviral effects of lamivudine and entecavir on patients with early-to-mid stage Hepatitis B related acute on chronic liver failure(HBV-ACLF).Methods A prospective,randomized,open and parallel controlled clinical trial was designed to observe the antiviral effects of nucleoside analogues on patients with early-to-mid stage HBV-ACLF.Three groups were set for controlled study,i.e.basic treatment group,lamivudine plus basic treatment group and entecavir plus basic treatment group.Results One month after treatment,the improvement rates of lamivudine group and entecavir group were 58.85% and 59.15% respectively,significantly hisher than that of basic treatment group which was 34.84%(X2=9.8323,P=0.043).By the end of six months,the cumulative survival rates of patients with the antiviral treatments,i.e.,lamivudine,entecavir,were 65.8%,60.1%,significantly higher than that(42%) without the antiviral treatment(P=0.045,P=0.04 respectively).The cumulative survival rate in patients with a MELD score <30 was higher than that with a MELD score over 30(X2= 3.920 P=0.048).For the patients with pretreatment HBV DNA≥107,the cumulative survival rate in patients with entecavir treatments group was higher than that of patients in basic treatment group(X2=5.014 P=0.025).According to the Ordinal Regression analysis,antiviral therapy by using either lamivudine or entecavia could significantly increase the improvement rate of patients with early-to-mid stage HBV-ACLF. But severe complications, including hepatorenal syndrome, electrolyte imbalance and hepatic encephalopathy,medical history of liver cirrhosis,and pretreatment HBV DNA≥107 had significant impacts on prognosis of this group patients.Conclusions Antiviral therapy by using either lamivudine or entecavia could significantly increase the survival rate of patients with early-to-mid stage HBV-ACLF.
