Efficacy of the 96-week adefovir dipivoxil therapy in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2010.03.021
- VernacularTitle:阿德福韦酯治疗慢性乙型病毒性肝炎96周疗效观察
- Author:
Zhen XU
1
;
Lu-Biao CHEN
;
Hong CAO
;
Xin SHU
;
Qi-Huan XU
;
Gang LI
;
Qi-Feng XIE
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B,chronic;
Adefovir dipivoxil;
DNA
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(3):224-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of the 96-week antiviral therapy with adefovir dipivoxil in patients with chronic hepatitis B.Methods 80 patients with chronic hepatitis B received the antiviral therapy of adefovir dipivoxil(ADV,10mg/d).At the 12th week,19 cases without early viral response(EVR,HBV DNA drop<2log10copies/ml)switched to the therapy of other nucleoside analogues.Aminotransferase(ALT)normalization,HBV DNA negative,HBeAg loss and HBeAg seroconvertion were accessed at the 96th week.Results At week 96,ALT normalization and HBV DNA negative in 61 patients with ADV therapy were 85.25%(52/61)and 95.08%(58/61);and HBeAg loss and HBeAg seroconvertion were 52.52%(17/33)and 42.42%(14/33)respectively.While for the other 19 patients switching to other nucleoside analogues.ALT normalization and HBV DNA negative came to 57.89%(11/19)and 68.42%(13/19).Both HBeAg lOtis and HBeAg seroconvertion were 58.33%(7/12).Conclusion Long term ADV antiviral therapy is effective to inhibit HBV DNA replications and benefits patients with chronic hepatits B.Switching to another nucleoside analogue is an optimal alternative if there is no EVR at week 12 in ADV therapy.
