Clinical significance of measuring hepatitis B virus large surface protein in serum
10.3760/cma.j.issn.1003-9279.2010.05.010
- VernacularTitle:血清乙型肝炎病毒大蛋白检测及其临床意义
- Author:
Nian-Yue WANG
1
;
Dai ZHANG
;
Yan-Wen GE
;
Wei ZHAO
Author Information
1. 东南大学附属第二医院
- Keywords:
Hepatitis B;
Viral envilope proteins;
DNA;
Biological markers
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(5):349-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of serum hepatitis B virus large protein( HBVLP) , HBV-DNA and markers of hepatitis B virus (HBV-M)in the diagnosis of viral replication. Methods Serum HBV-DNA level was quantitantively detected using PCR Real-time polymerase chain reaction, HBVLP was detected by enzyme-linked immunosorbent assay (ELISA) and HBV markers expression were measured by chemiluminescence immunoassay method in 1886 cases of seurm. Results The results of hepatitis virus large protein (HBV-LP) detection and the detection results of HBV-DNA was no significant difference (x2 = 1. 142,P ＞0. 05). HBV-DNA logarithm of copies and A vaule of HBV-LP was a positive correlation (r = 0. 487, P ＜ 0.01 ). HBV-DNA copies of different groups was significantly different from HBV-LPA values ( F = 7. 772, P ＜ 0. 01 ). The results of HBV-LP and HBV-DNA detected in different patterns of HBV-M were not significantly different. In 36 healthy people,the detecting results of HBV-DNA and HBV-LP are negetive. Conclusion There is a good correlation between the copies of HBV-DNA and the levels of HBV-LP. HBV-LP expression can reflect the replication of HBV.
