The expression of periphery blood leucocyte CCR3 and CCR5 in the children with Epstein-Barr virus associated infectious mononucleosis.
- Author:
Tie-xiong QI
1
;
Guo-hua GAO
;
Shi-hua LIU
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Gene Expression; Herpesvirus 4, Human; immunology; physiology; Humans; Infectious Mononucleosis; genetics; immunology; virology; Leukocytes; immunology; Male; Receptors, CCR3; genetics; immunology; Receptors, CCR5; genetics; immunology; T-Lymphocytes, Helper-Inducer; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2010;24(5):355-357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of periphery blood leucocyte CCR3 and CCR5 and to comprehend T helper cell in the Children with Epstein-Barr virus associated infectious mononucleosis.
METHODSWe defined the children according to the diagnosis criterion through Paul-Bunnell test inspecting the children's periphery blood unusual lymphocyte and detecting their anti-EBV-CA-IgM, anti-EBV-CA-IgG and anti-EBV-NA-IgG by ELISA and counted the ratio of CCR3 + and CCR5 + cells in lymphocytes with flow cytometry.
RESULTSThe ratio of unusual lymphocyte in IM was higher than that of the healthy control group (P < 0.05). The ratio of CCR3 + cells in IM group was higher than that of the healthy control group (P < 0.05). The ratio of CCR5 + cells in IM group was significantly lower than that of the healthy control group. CCR3 + had direct interrelation with fever continued time and the ratio of unusual lymphocyte. There was a negative interrelation between CCR5 and fever continued time (P < 0.05).
CONCLUSIONSChildren infectious of IM expressed higher level of CCR3 + and lower level of CCR5 + and there was a tendency of Th2 polarization with over production of T helper cell divide imbalance. CCR3 + and CCR5 + may be important targets to judge the degree of seriousness of IM.
