The expression of periphery blood leucocyte CCR3 and CCR5 in the children with Epstein-Barr virus associated infectious mononucleosis
10.3760/cma.j.issn.1003-9279.2010.05.012
- VernacularTitle:感染EB病毒的传染性单核细胞增多症患儿外周血白细胞CCR3和CCR5的表达
- Author:
Tie-Xiong QI
1
;
Guo-Hua GAO
;
Shi-Hua LIU
Author Information
1. 航空工业中心医院
- Keywords:
Herpesvirus 4,human;
Infectious mononucleosis;
Receptors,CCR3;
Receptors,CCR5;
T-Lymphocyte subsets
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(5):355-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of periphery blood leucocyte CCR3 and CCR5 and to comprehend T helper cell in the Children with Epstein-Barr virus associated infectious mononucleosis.Methods We defined the children according to the diagnosis criterion through Paul-Bunnell test inspecting the children's periphery blood unusual lymphocyte and detecting their anti-EBV-CA-IgM, anti-EBV-CA-IgG and anti-EBV-NA-IgG by ELISA and counted the ratio of CCR3 + and CCR5 + cells in lymphocytes with flow cytometry. Results The ratio of unusual lymphocyte in IM was higher than that of the healthy control group (P ＜ O. 05). The ratio of CCR3 + cells in IM group was higher than that of the healthy control group (P ＜ 0.05). The ratio of CCR5 + cells in IM group was significantly lower than that of the healthy control group. CCR3 + had direct interrelation with fever continued time and the ratio of unusual lymphocyte. There was a negative interrelation between CCR5 and fever continued time ( P ＜ 0. 05 ). Conclusions Children infectious of IM expressed higher level of CCR3 + and lower level of CCR5 + and there was a tendency of Th2 polarization with over production of T helper cell divide imbalance. CCR3 + and CCR5 + may be important targets to judge the degree of seriousness of IM.
