Detection of BK virus infection in renal transplant recipients and clinical application.
- Author:
Zhong-biao WU
1
;
Guo-bing LIN
;
Ai-ping ZENG
;
Zhen-qian CHEN
;
Jun CHEN
;
Min-qiao ZHENG
;
Guo-wei TU
;
Rui-ming RONG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; BK Virus; genetics; isolation & purification; physiology; Female; Humans; Kidney; virology; Kidney Transplantation; Male; Middle Aged; Polyomavirus Infections; diagnosis; virology; Postoperative Complications; diagnosis; virology; Tumor Virus Infections; diagnosis; virology; Virus Replication; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2010;24(5):367-369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the detection methods of BK virus infection in kidney transplant recipients, and to explore the clinical application.
METHODS132 cases of renal transplant recipients were undertaken BK virus detection including presence of decoy cells in urinary sediment, urine and serum BKV-DNA to demonstrate the BK virus replication.
RESULTAmong 132 cases of renal transplant recipients, urinary decoy cell was found in 37 (28.0%) patients and the median time was 12 months after surgery. 32 (24.2%) patients were diagnosed as BK viruria at a median of 11 months after surgery, and 16 (12.1%) recipients were diagnosed as BK viremia at a median of 15 months after surgery, 5 patients with BK viruria were diagnosed as BK virus associated nephropathy according to allograft biopsy.
CONCLUSIONTo make early diagnosis of BK virus infection, detection of urine decoy cells and BKV-DNA in urine and plasma sample is important,which provides an important basis for the prevention of BK virus associated nephropathy.
