Detection of BK virus infection in renal transplant recipents and clinical application

VernacularTitle:肾移植术后BK病毒感染的检测及临床意义
Author: Zhong-Biao WU ¹ ; Guo-Bing LIN ; Ai-Ping ZENG ; Zhen-Qian CHEN ; Jun CHEN ; Min-Qiao ZHENG ; Guo-Wei TU ; Rui-Ming RONG
Author Information

1. 浙江省温岭市第一人民医院
Keywords: kidney transplantation; BK virus; Cell count; Nephrosis
From: Chinese Journal of Experimental and Clinical Virology 2010;24(5):367-369
CountryChina
Language:Chinese
Abstract: Objective To study the detection methods of BK virus infection in kidney transplant recipients, and to explore the clinical application. Methods 132 cases of renal transplant recipients were undertaken BK virus detection including presence of decoy cells in urinary sediment, urine and serum BKVDNA to demonstrate the BK virus replication. Result Among 132 cases of renal transplant recipients,urinary decoy cell was found in 37 (28.0%)patients and the median time was 12 months after surgery. 32(24. 2% )patients were diagnosed as BK viruria at a median of 11 months after surgery, and 16( 12. 1% )recipients were diagnosed as BK viremia at a median of 15 months after surgery, 5 patients with BK viruria were diagnosed as BK virus associated nephropathy according to allograft biopsy. Conclusion To make early diagnosis of BK virus infection, detection of urine decoy cells and BKV-DNA in urine and plasma sample is important,which provides an important basis for the prevention of BK virus associated nephropathy.