Study on HLA-DRB1 alleles in patients with familial hepatitis B in Shanxi.
- Author:
Xiao-Yu HE
1
;
Liao-Yun ZHANG
;
Xiao-Hong ZHANG
;
De-Mei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Hepatitis B; genetics; immunology; Humans; Male
- From: Chinese Journal of Experimental and Clinical Virology 2010;24(6):418-420
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between HLA-DRB1 alleles and familial hepatitis B.
METHODSHLA-DRB1 alleles of 151 people in the familial hepatitis B families were detected,by using the the polymerase chain reaction-sequence specific oligonucleotide probing (PCR-SSOP) technique.
RESULTSThe allele frequency of HLA-DRB1 * 0701 in the chronic hepatitis B (CHB) group was markedly higher than that in the normal control group (17.8% vs 7.4%), with significant correlation between them (P < 0.05, A = 1/0.367 approximately 2.725). The allele frequencies of HLA-DRB1 * 0401/0403/0405 and HLA-DRB1 * 1301/1302 in the normal control group (16.2%, 4.4% ) were markedly higher than that in the CHB group (5.1%, 0), with statistical significance (P < 0.05, A = 3.602; P < 0.05). The other alleles between the CHB group and the normal control group are no significant differences.
CONCLUSIONHLA-DRB1 * 0701 is closely associated with the susceptibility to familial hepatitis B,and may be the susceptible or linkage gene. HLA-DRB1* 0401/0403/0405 and HLA-DRB1 * 1301/1302,in inverse proportion to the susceptibility to familial hepatitis B, may be the resistant gene. They may regulate the outcome of familial HBV infection in a patient.
