Study on HLA-DRB1 alleles in patients with familial hepatitis B in Shanxi
10.3760/cma.j.issn.1003-9279.2010.06.008
- VernacularTitle:山西省家族性乙型肝炎病例中HLA-DRB1基因位点的分析
- Author:
Xiao-Yu HE
1
;
Liao-Yun ZHANG
;
Xiao-Hong ZHANG
;
De-Mei ZHANG
Author Information
1. 山西医科大学第一临床医学院
- Keywords:
Hepatitis S B,chronic;
HLA-DRB1 antigen;
Polymerase chain reaction;
Genotype
- From:
Chinese Journal of Experimental and Clinical Virology
2010;24(6):418-420
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between HLA-DRB1 alleles and familial hepatitis B. Methods HLA-DRB1 alleles of 151 people in the familial hepatitis B families were detected,by using the the polymerase chain reaction-sequence specific oligonucleotide probing(PCR-SSOP) technique. Results The allele frequency of HLA-DRB1 * 0701 in the chronic hepatitis B(CHB) group was markedly higher than that in the normal control group( 17.8% vs 7.4% ), with significant correlation between them (P ＜0.05, A = 1/0. 367 ≈2. 725 ). The allele frequencies of HLA-DRB1 * 0401/0403/0405 and HLA-DRB1 *1301/1302 in the normal control group( 16. 2% ,4.4% ) were markedly higher than that in the CHB group (5. 1% ,0) ,with statistical significance ( P ＜ 0. 05, A = 3. 602; P ＜ 0. 05 ). The other alleles between the CHB group and the normal control group are no significant differences. Conclusion HLA-DRB1 * 0701 is closely associated with the susceptibility to familial hepatitis B ,and may be the susceptible or linkage gene.HLA-DRB1 * 0401/0403/0405 and HLA-DRB1 * 1301/1302,in inverse proportion to the susceptibility to familial hepatitis B,may be the resistant gene. They may regulate the outcome of familial HBV infection in a patient.
