Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen.
- Author:
Zi-Qiang ZHOU
1
;
Dong-Ping YE
;
Wei-Guo LIANG
;
Bin WANG
;
Zhen-Zhong ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Cements; chemistry; therapeutic use; Calcium Phosphates; chemistry; Collagen; chemistry; Compressive Strength; Histocompatibility Testing; Injections; Rabbits; Strontium; chemistry
- From: Chinese Journal of Traumatology 2015;18(1):33-38
- CountryChina
- Language:English
-
Abstract:
PURPOSETo develop a novel injectable strontium-containing calcium phosphate cement with collagen.
METHODSA novel calcium phosphate bone cement (CPC) was prepared with the addition of strontium element, collagenl, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated.
RESULTSThe results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained (48.0 MPa ± 2.3 MPa); histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of cement was consistent with the new bone growth.
CONCLUSIONA novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good anti-washout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.