Ginkgolide B inhibits carotid sinus baroreflex in anesthetized male rats.
- Author:
Chun-Yan WANG
1
;
Yu-Ming WU
;
Lin XIAO
;
Hong-Mei XUE
;
Ru WANG
;
Fu-Wei WANG
;
Rui-Rong HE
Author Information
1. Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
- Publication Type:Journal Article
- MeSH:
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester;
pharmacology;
Animals;
Baroreflex;
drug effects;
Calcium Channel Agonists;
pharmacology;
Calcium Channels, L-Type;
Carotid Sinus;
physiopathology;
Ginkgolides;
pharmacology;
Lactones;
pharmacology;
Male;
Potassium Channel Blockers;
pharmacology;
Pressoreceptors;
metabolism;
Rats;
Rats, Sprague-Dawley;
Tetraethylammonium;
pharmacology
- From:
Acta Physiologica Sinica
2008;60(1):17-22
- CountryChina
- Language:English
-
Abstract:
The effects of ginkgolide B on the carotid sinus baroreflex (CSB) were studied in the perfused isolated carotid sinus of 30 anesthetized Sprague-Dawley male rats. The results were as follows. (1) By perfusing with ginkgolide B (0.1, 1, 10 μmol/L), the functional curve of the baroreflex was shifted to the right and upward. There was a marked decrease in peak slope (PS) and reflex decrease (RD) in mean arterial pressure (P<0.01), while the threshold pressure (TP), equilibrium pressure (EP) and saturation pressure (SP) were significantly increased (P<0.05, P<0.01). Among the functional parameters of CSB, the changes in PS, RD, TP, EP and SP were dose-dependent. (2) Pretreatment with Bay K8644 (500 nmol/L), an agonist of L-type calcium channel, completely eliminated the effects of ginkgolide B (1 μmol/L) on the CSB. (3) Pretreatment with tetraethylammonium (TEA, 1 mmol/L), an inhibitor of potassium channel, completely abolished the above effects of ginkgolide B (1 μmol/L) on the CSB. These results suggest that ginkgolide B inhibits the CSB in anesthetized rats, which is mediated by decreased calcium influx and increased potassium efflux in baroreceptor nerve endings.
