Role of vasculogenic mimicry and endothelium-dependent vessel in metastasis of laryngeal cancer.

Wei Wang; Peng Lin; Bao-cun Sun; Wen-juan Cai; Chun-rong Han; Li LI; Hong-hua LU; Jin-mei Zhang

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Role of vasculogenic mimicry and endothelium-dependent vessel in metastasis of laryngeal cancer.

Author: Wei WANG ¹ ; Peng LIN ; Bao-cun SUN ; Wen-juan CAI ; Chun-rong HAN ; Li LI ; Hong-hua LU ; Jin-mei ZHANG
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1. Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin Otorhinolaryngology Institution, the First Clinical Department of Tianjin Medical University, Tianjin 300384, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Carcinoma, Squamous Cell; blood supply; diagnosis; pathology; Endothelium, Vascular; Female; Head and Neck Neoplasms; blood supply; diagnosis; pathology; Humans; Laryngeal Neoplasms; blood supply; diagnosis; pathology; Lymphatic Metastasis; Male; Middle Aged; Neovascularization, Pathologic; Prognosis; Retrospective Studies
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(5):400-405
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the contribution of vasculogenic mimicry (VM) and endothelium-dependent vessel (EDV) to invasion and metastasis of laryngeal squamous cell carcinoma (LSCC).
METHODSA total of 203 cases with LSCC was reviewed and followed up. VM and EDV in LSCC tissues were assessed by double staining with anti-CD31 immunohistochemistry and periodic acid-schiff. Kruskal-Wallis test and one-way ANOVA were used to analyze the relationship between VM, EDV and clinical pathology parameters of LSCC. Kaplan-Meier analysis was used to evaluate overall survival (OS) of patients with LSCC.
RESULTSVM related to pTNM stage, lymph node metastasis and pathology grade of LSCC, while EDV related to primary sites, pTNM stage, T stage and distant metastasis of LSCC. Univariate analysis showed VM (P = 0.014), pTNM stage (P = 0.009), T stage (P = 0.013), nodal status (P = 0.013), histopathology grade (P = 0.038), tumor size (P = 0.028), and radiotherapy (P < 0.0001) related to OS. VM (P = 0.011), primary sites (P = 0.049), tumor size (P = 0.001) and radiotherapy (P < 0.0001) related to disease free survival. Multivariate analysis indicated that VM was an adverse predictor for both OS and disease free survival.
CONCLUSIONSBoth VM and EDV existed in LSCC. VM contributed to progression of LSCC through promoting lymph node metastasis. VM is an independent predictor for the prognosis of LSCC.