Efficacy and safety analysis with standardized mite allergen subcutaneous immunotherapy in 90 patients with allergic rhinitis
10.3760/cma.j.issn.1673-0860.2012.06.002
- VernacularTitle:变应性鼻炎标准化螨变应原皮下免疫治疗患者的疗效及安全性
- Author:
Lin LI
1
;
Gui-Mei GUAN
;
Dong-Dong ZHU
;
Ji-Chao SHA
;
Guang-Hua JIN
;
Ming-Xing CHEN
;
Hong ZHANG
;
Zhen DONG
Author Information
1. 吉林大学中日联谊医院
- Keywords:
Rhinitis,allergic, perennial;
Desensitization,immunologic;
Antigens,dermatophagoides;
Treatment outcome
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2012;47(6):445-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the three-year efficacy and safety with standardized dust mite subcutaneous immunotherapy in patients with allergic rhinitis. Methods Ninety patients who were diagnosed as allergic to mite by skin prick test and serum IgE were include in the standardized allergenspecific dose-escalation regimen.Nasal symptom score (0 - 3 ) were collected before treatment and three years after treatment; VAS( visual analogue scale,0 - 10) of all nasal symptoms and drug use score were collected every four months; frequency of local and systemic reactions were recorded in the duration of dose escalation and maintenance.Results Nasal blocking,sneeze,rhinorrhia and nasal itch were significantly improved after 3 years treatment ( before treatment:2 [ 2 ; 3 ],2 [ 2 ;3 ],2 [ 2 ;3 ],2 [ 1 ; 2 ] ; after treatment:all were 0 [ 0 ;0 ] ; Z value were - 8.310,- 8.408,- 8.377,- 8.287,all P were 0.000 ).VAS of all nasal symptoms and drug use score decreased dramatically after escalation period ( before treatment:8.00 [7.00;8.85],2.00[ 1.50;2.00] ; after treatment:1.00[ 1.00;1.50],0 [0;0] ; Z value were -8.287,- 8.248,P value 0.086,0.744 ),and maintained afterwards ( F value were 2.483,0.296 ; P value were 0.086,0.744).Ninty-eight case times (64.47％ ) local reactions mainly happened in maintenance period;the frequency of systemic reactions was 2.54％. Conclusion The standardized specific allergen immunotherapy for allergic rhinitis is safe and effective.
