Single-agent maintenance therapy in non-small cell lung cancer: a systematic review and meta-analysis.
- Author:
Dong-Mei YUAN
1
;
Shu-Zhen WEI
;
Yan-Ling LÜ
;
Yan ZHANG
;
Xiao-Hui MIAO
;
Ping ZHAN
;
Li-Ke YU
;
Yi SHI
;
Yong SONG
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; adverse effects; therapeutic use; Carcinoma, Non-Small-Cell Lung; drug therapy; mortality; Disease-Free Survival; Humans; Lung Neoplasms; drug therapy; mortality; Publication Bias
- From: Chinese Medical Journal 2012;125(17):3143-3149
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDCan single-agent maintenance therapy be considered as an ideal strategy for non-small cell lung cancer (NSCLC) treatment to achieve prolonged survival and tolerated toxicity? A systematic review and meta-analysis was performed to elucidate this issue.
METHODSThe electronic databases were searched for RCTs comparing single-agent maintenance therapy with placebo, best support care or observation. The required data for estimation of response, survival and toxicity were extracted from the publications and the combined data were calculated.
RESULTSEleven RCTs involving 3686 patients were identified. We found a statistically significant higher probability of tumor response for patients with maintenance therapy versus control patients (OR: 2.80, 95%CI: 2.15 - 3.64). Patients receiving maintenance therapy had significantly longer progression-free survival (PFS) (HR: 0.67, 95%CI: 0.62 - 0.71) and overall survival (OS) (HR: 0.84, 95%CI: 0.78 - 0.90). However, maintenance therapy was associated with more severe toxicities (OR: 6.45, 95%CI: 4.61 - 9.01).
CONCLUSIONIn patients with advanced NSCLC, the use of single-agent maintenance therapy is associated with higher response rate and significantly prolongs PFS and OS despite of the risk of additional toxicity.