Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.
- Author:
Tolga Sinan GÜVENÇ
1
;
Emel CELIKER
;
Kazim Serhan OZCAN
;
Erkan ILHAN
;
Mehmet EREN
Author Information
1. Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey. tsguvenc@gmail.com
- Publication Type:Case Reports
- MeSH:
Capecitabine;
Coronary Thrombosis;
chemically induced;
Coronary Vasospasm;
chemically induced;
Deoxycytidine;
adverse effects;
analogs & derivatives;
therapeutic use;
Female;
Fluorouracil;
adverse effects;
analogs & derivatives;
therapeutic use;
Humans;
Middle Aged;
Myocardial Infarction;
chemically induced
- From:
Chinese Medical Journal
2012;125(18):3349-3351
- CountryChina
- Language:English
-
Abstract:
Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion. Capecitabine and its active metabolite, 5-FU, have cardiotoxic effects with reported instances of acute coronary syndromes caused due to coronary vasospasm. However, these agents exert toxic effects on cardiovascular system and beyond vasospasm provacation. We report a 46-year-old patient diagnosed as acute inferior infarction who is treated with capecitabine for 3 months due to metastatic breast carcinoma, in whom thrombotic coronary occlusion was observed in angiography. This case demonstrates that apart from vasospasm, coronary thrombosis could be observed after capecitabine treatment, with a possible direct effect of this drug.
