Effect of native aortic valve sparing aortic root reconstruction surgery on short-and long-term prognosis in Marfan syndrome patients: a meta-analysis
10.3760/cma.j.issn.0253-3758.2014.05.018
- VernacularTitle:主动脉根部手术中保留主动脉瓣对马方综合征患者早期和远期预后影响的荟萃分析
- Author:
Rui HU
1
;
Zhiwei WANG
;
Xiaoping HU
;
Hongbing WU
;
Zhen ZHOU
Author Information
1. 430060,武汉大学人民医院心血管外科
- Keywords:
Marfan syndrome;
Cardiac surgical procedures;
Aortic valve;
Meta-analysis
- From:
Chinese Journal of Cardiology
2014;42(5):433-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective This meta-analysis was performed to analyze the effect ot preserving the native aortic valve on short-and long-term prognosis post aortic root reconstruction surgery for patients with Marfan syndrome.Methods Database including Pubmed,Embase,Cochrane library,CNKI,Wanfang,VIP and CBM were searched to collect studies comparing clinical results of valve sparing surgery with composite valve graft surgery for patients with Marfan syndrome.Study quality was assessed by Newcastle-Ottawa Scale and publication bias was assessed by visual inspection of the funnel plot together with Egger test.Clinical outcomes data was extracted from the manuscripts and analyzed with Revman 5.0 supplied by Cochrane collaboration.Results Seven clinical trials with 690 patients were included.Meta-analysis demonstrated that valve sparing surgery was associated with a lower incidence of re-exploration(RR =0.51,95％ CI:0.29-0.90,P ＜ 0.05),thromboembolism (RR =0.17,95 ％ CI:0.05-0.57,P ＜ 0.01),endocarditis (RR =0.31,95 ％ CI:0.11-0.94,P ＜ 0.05) and significantly lower long-term death rate (RR =0.37,95 ％ CI:0.18-0.74,P ＜ 0.01).Reoperation rate was similar between the two groups(RR =1.07,95％ CI:0.35-3.27,P ＞ 0.05).Conclusion Valve sparing aortic root reconstruction surgery is a superior procedure to composite valve graft surgery in term of improving the short-and long-term prognosis for patients with Marfan syndrome.
