Autopsy pathological characteristics in coronary artery disease patients with or without sudden cardiac death
10.3760/cma.j.issn.0253-3758.2014.06.012
- VernacularTitle:冠状动脉粥样硬化症及其猝死的尸检病理学分析
- Author:
Botao LUO
1
;
Jie RAO
;
Lirong ZHAO
;
Wei JIE
;
Hanguo JIANG
Author Information
1. 广东医学院病理学教研室
- Keywords:
Coronary arteriosclerosis;
Death,sudden,cardiac;
Autopsy;
Pathology,clinical
- From:
Chinese Journal of Cardiology
2014;42(6):487-491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare clinicopathological characteristics of coronary artery disease (CAD) patients with or without sudden coronary death(SCD).Methods A total of 145 autopsy cases with CAD were divided into SCD group(38 cases)and non-SCD group (107 cases).The difference on age,number of diseased coronary vessel,coronary athemsclerotic stage (fatty streak stage,fibrous plaque stage and atheromatous plaque stage),composite lesions of coronary artery,grade of stenosis severity,acute myocardial infarction,old myocardial infarction,hypertensive cardiomyopathy,myocardial fatty infiltration and arteriosclerosis of the arteries on the base of the brain were compared between SCD group and non-SCD group.Results (1) Patients were older in SCD group than in non-SCD group [(55.3 ± 14.5) years vs.(48.5 ± 13.3) years,P ＜ 0.01].(2) There was a significant positive correlation between coronary atherosclerotic stage and grade of coronary stenosis severity (rs =0.79,P ＜ 0.01).(3) The rate of multiple vessel disease,coronary atherosclerotic stage,composite lesions of coronary artery,grade Ⅲ-Ⅳ coronary artery stenosis,old myocardial infarction and arteriosclerosis of the arteries on the base of the brain were 60.5％ (23/38),84.2％ (32/38),63.2％ (24/38),86.8％ (33/38),36.8％ (14/38) and 34.2％ (13/ 38),respectively in SCD group,which were significantly higher than those in non-SCD group [25.2％ (27/ 107),29.0％ (31/107),18.7％ (20/107),19.6％ (21/107),3.7％ (4/107) and 6.5％ (7/107),respectively,all P ＜ 0.01].Conclusion Coronary artery atherosclerotic lesion is severer and patients are older in SCD patients than in non-SCD patients in this coronary artery disease patient cohort.
