Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors.
- Author:
Hua HU
1
;
Hong-tian YAO
;
Wei-ping ZHANG
;
Lei ZHANG
;
Wei DING
;
Shi-hong ZHANG
;
Zhong CHEN
;
Er-qing WEI
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Aged, 80 and over; Aquaporin 4; Aquaporins; metabolism; Biomarkers; metabolism; Brain Edema; etiology; metabolism; pathology; Brain Injuries; complications; metabolism; pathology; Brain Neoplasms; complications; metabolism; pathology; Female; Humans; Male; Middle Aged; Tissue Distribution
- From: Journal of Zhejiang University. Science. B 2005;6(1):33-37
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo characterize the expression of aquaporin-4 (AQP4), one of the aquaporins (AQPs), in human brain specimens from patients with traumatic brain injury or brain tumors.
METHODSNineteen human brain specimens were obtained from the patients with traumatic brain injury, brain tumors, benign meningioma or early stage hemorrhagic stroke. MRI or CT imaging was used to assess brain edema. Hematoxylin and eosin staining were used to evaluate cell damage. Immunohistochemistry was used to detect the AQP4 expression.
RESULTSAQP4 expression was increased from 15 h to at least 8 d after injury. AQP4 immunoreactivity was strong around astrocytomas, ganglioglioma and metastatic adenocarcinoma. However, AQP4 immunoreactivity was only found in the centers of astrocytomas and ganglioglioma, but not in metastatic adenocarcinoma derived from lung.
CONCLUSIONAQP4 expression increases in human brains after traumatic brain injury, within brain-derived tumors, and around brain tumors.
