Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: neopterin and interleukin-2.
- Author:
Min YAN
1
;
Gang CHEN
;
Ling-ling FANG
;
Zi-ming LIU
;
Xiu-lai ZHANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Blood Transfusion, Autologous; adverse effects; methods; Female; Humans; Interleukin-2; blood; immunology; Male; Middle Aged; Neopterin; blood; immunology; Perioperative Care; adverse effects; methods; Postgastrectomy Syndromes; blood; etiology; immunology; Stomach Neoplasms; blood; immunology; surgery; Treatment Outcome
- From: Journal of Zhejiang University. Science. B 2005;6(1):49-52
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The Serum Neopterin and Interleukin-2 (IL-2) were measured.
METHODSSixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups: (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared.
RESULTSIn group A, Serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both Serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, Serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation.
CONCLUSIONAutologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.
