Correlation of plasma adiponectin and components of metabolic syndrome.
- Author:
Shi-Xiu ZHANG
1
;
Hong-Wei GUO
;
Wen-Tao WAN
;
Kun XUE
Author Information
- Publication Type:Journal Article
- MeSH: Adiponectin; blood; Adolescent; Adult; Aged; Blood Pressure; Body Mass Index; China; Cluster Analysis; Female; Humans; Insulin Resistance; Male; Metabolic Syndrome; blood; epidemiology; Middle Aged; Obesity, Abdominal; epidemiology; Principal Component Analysis; Young Adult
- From: Chinese Journal of Preventive Medicine 2009;43(6):522-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the relationship of adiponectin and the components of metabolic syndrome (MS).
METHODSCluster random sampling was applied in two districts of Shanghai. Two communities were selected. After investigating and physical examination, 235 MS subjects were obtained. Correlation analysis and principle components regression analysis were used to analyze the relationship between adiponectin and components of MS (waist circumference, blood pressure, blood glucose and lipid).
RESULTSAdiponectin in male was (2.82 +/- 1.73) microg/ml, lower than in female [(5.12 +/- 3.51) microg/ml] with statistical difference (Z = -5.25, P = 0.00). Adiponectin levels [(4.38 +/- 3.23) microg/ ml] correlated with abdominal obesity, including waist circumference [(93.37 +/- 7.76) cm] (r(s) = - 0.18, t(r) = -2.79, P = 0.01) and waist hip ratio (0.91 +/- 0.05) (r(s) = -0.28, t(r) = -4.44, P = 0.00), but did not correlate significantly with body mass index (BMI) [(26.85 +/- 3.10) kg/m2] (r(s) = -0.10, t(r) = - 1.45, P = 0. 15). Adiponectin correlated negatively with insulin resistance related indexes, including fasting glucose [(5.48 +/- 1.72) mmol/L] (r(s) = -0.13, t(r) = -2.00, P = 0.05), fasting insulin [(11.52 +/- 5.34) mU/L] (r(s) = -0. 15, t(r) = - 2.31, P = 0.02), homeostasis model assessment of insulin resistance (HOMA-IR) (2.90 +/- 2.07) (r(s) = -0.17, t(r) = -2.63, P = 0.01) and triglyceride [(2.11 +/- 1.24) mmol/L] (r(s) = -0.24, t(r) = -3.77, P = 0.00). The correlations were not observed between adiponectin with total cholesterol [(5.01 +/- 1.19) mmol/L] ( r(s) = -0.05, t(r) = -0.78, P = 0.44), high density lipoprotein-cholesterol (HDL-C) [(1.21 +/- 0.32) mmol/L] (r(s) = 0.06, t(r) = 0.93, P = 0.36), systolic blood pressure [(131.40 +/- 14.93) mm Hg, 1 mm Hg = 0.133 kPa] (r(s) = -0.02, t(r) = -0.34, P = 0.73) and diastolic blood pressure [(86.77 +/- 9.14)mm Hg] (r(s) = -0.02, t(r) = -0.27, P = 0.78).
CONCLUSIONAdiponectin should correlate negatively with abdominal obesity and insulin resistance, but not directly correlate with blood pressure in MS.
