WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study.
- Author:
Jin Man KIM
1
;
Young Hyeh KO
;
Seung Sook LEE
;
Jooryung HUH
;
Chang Suk KANG
;
Chul Woo KIM
;
Yun Kyung KANG
;
Jai Hyang GO
;
Min Kyung KIM
;
Wan Seop KIM
;
Yoon Jung KIM
;
Hyun Jung KIM
;
Hee Kyung KIM
;
Jong Hee NAM
;
Hyung Bae MOON
;
Chan Kum PARK
;
Tae In PARK
;
Young Ha OH
;
Dong Wha LEE
;
Jong Sil LEE
;
Juhie LEE
;
Hyekyung LEE
;
Sung Chul LIM
;
Kyu Yun JANG
;
Hee Kyung CHANG
;
Yoon Kyung JEON
;
Hye Ra JUNG
;
Min Sun CHO
;
Hee Jeong CHA
;
Suk Jin CHOI
;
Jae Ho HAN
;
Sook Hee HONG
;
Insun KIM
Author Information
- Publication Type:Original Article
- Keywords: Lymphoma; Malignant; WHO; Korea
- MeSH: Academies and Institutes; Delivery of Health Care; Hodgkin Disease; Korea; Lymphocytes; Lymphoid Tissue; Lymphoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Sclerosis; World Health Organization
- From:Korean Journal of Pathology 2011;45(3):254-260
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. METHODS: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. RESULTS: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed. CONCLUSIONS: Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.
