Experimental study on anti-tumor effect of extractive from Celastrus orbiculatus in vivo.
- Author:
Jian ZHANG
1
;
Yun-Ming XU
;
Wei-Min WANG
;
Yan-Qing LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; isolation & purification; pharmacology; Antioxidants; isolation & purification; pharmacology; Celastrus; chemistry; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Liver Neoplasms, Experimental; blood; pathology; Male; Malondialdehyde; blood; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Plant Stems; chemistry; Plants, Medicinal; chemistry; Sarcoma 180; blood; pathology; Superoxide Dismutase; blood
- From: China Journal of Chinese Materia Medica 2006;31(18):1514-1516
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-tumor activity of extractive from Celastrus orbiculatus in vivo.
METHODMice bearing transplanted tumor S180 and Heps were used to study the effects of acetoacetate and n-butanol extractive from C. orbiculatus. The changes in serum contents of SOD and malondialdehyde (MDA) content were assayed.
RESULTAcetoacetate and n-butanol extractive from C. orbiculatus significantly inhibited the growth of S180 and Heps tumor in mice. SOD content was obviously increased, MDA content obviously decreased in the serum after extractive treatment.
CONCLUSIONAcetoacetate and n-butanol extractive from C. orbiculatus have anti-tumor effects and anti-oxidative capacity.
