Studies on diterpenoids from Andrographis paniculata.
- Author:
Li-Xia CHEN
1
;
Ge-Xia QU
;
Feng QIU
Author Information
- Publication Type:Journal Article
- MeSH: Andrographis; chemistry; Diterpenes; chemistry; isolation & purification; Glucosides; chemistry; isolation & purification; Molecular Structure; Plant Components, Aerial; chemistry; Plants, Medicinal; chemistry; Tetrahydronaphthalenes; chemistry; isolation & purification
- From: China Journal of Chinese Materia Medica 2006;31(19):1594-1597
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the diterpenoids in the 85% ethanol extract of the aerial parts of Andrographis paniculata.
METHODFourteen diterpenoids from the 85% EtOH extract were isolated by the silica gel, Sephadex LH-20, ODS column chromatography and HPLC, and their structures were identified by the spectal analyses and chemical evidences.
RESULTThe 14 compounds were obtained and identified as neoandrographolide (1), 3, 14-di-deoxyandrographolide (2), andrographolide (3), 14-deoxy-11, 12-didehydroandrographolide (4), 19-hydroxy-8 (17), 13-labdadien-15, 16-olide (5), 14-deoxy-andrographolide (6), 3-oxo-14-deoxy-andrographolide (7), isoandrographolide, (8), bisandrographolide (9, 10, 11), deoxyandrographiside (12), 14-deoxy-11, 12-didehydroandrographiside (13), andrographiside (14), respectively.
CONCLUSIONCompound 7 was a new natural product, and compound 5 was obtained for the first time from the Andrographis species.
