Study on irritation of calcium oxalate crystal in raw Pinellia ternata.
- Author:
Ling-Yun ZHONG
1
;
Hao WU
;
Ke-Wei ZHANG
;
Qian-Ru WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Calcium Oxalate; chemistry; isolation & purification; toxicity; Conjunctiva; drug effects; Cornea; drug effects; Crystallization; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; isolation & purification; toxicity; Edema; chemically induced; Eye Diseases; chemically induced; Female; Iris; drug effects; Male; Pinellia; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rabbits; Random Allocation; Rubia; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(20):1706-1710
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEConfirm the irritation of needle-like calcium oxalate crystals in raw Pinellia ternata.
METHODComparing the irritations of raw P. ternate containing calcium oxalate crystals, the raw P. ternate no containing calcium oxalate crystals, the pure needle-like calcium oxalate crystals isolated from raw P. ternata, the extracts of water and various solvents from raw P. ternate. by using the model of rabbits' eyes. Studying the quantity effect relationship of different concentration suspensions of needle-like calcium oxalate crystal isolated from raw P. ternate on rabbits' eyes. Observing the shape and appearance of calcium oxalate crystals in raw P. ternate and raw India Madder Root by the electro microscope and comparing their irritation degrees with the same contents of calcium oxalate crystals.
RESULTCalcium oxalate crystals in raw P. ternata showed very strong irritation property. Under the same content of calcium oxalate crystals, the irritation of raw P. ternata and pure needle-like calcium oxalate crystals isolated from raw P. ternate had no significant difference. The concentrations of needle-like calcium oxalate crystals were do relative to the degree of irritation on rabbits' eyes and they showed undoubted quantity-effect relationship.
CONCLUSIONCalcium oxalate crystal is the irritation component in raw P. ternata.
