Mechanism study of anti-influenza effects of Radix Isatidis water extract by red blood cells capillary electrophoresis.
- Author:
Zhi-Wei CHEN
1
;
Ling-Wei WU
;
Shu-Tao LIU
;
Chun-Ping CAI
;
Ping-Fan RAO
;
Li-Jing KE
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; isolation & purification; pharmacology; Drugs, Chinese Herbal; isolation & purification; pharmacology; Electrophoresis, Capillary; Erythrocytes; ultrastructure; virology; Hemagglutination Inhibition Tests; Humans; Influenza A virus; drug effects; Isatis; chemistry; Male; Plant Roots; chemistry; Plants, Medicinal; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(20):1715-1719
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the mechanism of the inhibition effects of BWE on cell attachment of influenza virus by capillary electrophoresis.
METHODThe morphologic difference of red cells after treating with BWE infected by influenza virus was detected with microscope, capillary electrophoresis and HA.
RESULTThe pretreatment of the normal cells with BWE inhibited the attachment of influenza to the cells, while no meaningful inhibition was observed when influenza virus was pretreated before being inoculated to cells.
CONCLUSIONThe results indicate that the inhibition effects of BWE on cell attachment of influenza virus may be an important mechanism of anti-influenza activity of Radix Isatidis Extracts.
