Clinical Studies in Patients with HLA-B 27 Positive Uveitis.
- Author:
Tae Gyung KIM
1
;
Min Ho KIM
;
Jin Sung YOO
;
Warne HUH
Author Information
1. Department of Ophthalmology, Kangnam St.Mary's Hospital, The Catholic University of Korea, College of Medicine.
- Publication Type:Original Article
- Keywords:
HLA B27;
HLA B27 positive Uveitis;
HLA typing
- MeSH:
Arthralgia;
Chorioretinitis;
Histocompatibility Testing;
HLA-B Antigens*;
Humans;
Inflammation;
Ophthalmic Solutions;
Ophthalmology;
Oral Ulcer;
Prognosis;
Retinaldehyde;
Skin;
Spondylitis, Ankylosing;
Ulcer;
Uveitis*;
Uveitis, Anterior;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2000;41(1):67-73
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is well known that HLA-B 27-associated uveitis is mostly anterior uveitis and has systemic manifestations.20 Patients [27 eyes]followed up at department of Ophthalmology of Kangnam St.Mary`s hospital, Catholic University Medical College from November 1989 to June 1998, were studied to delineate the clinical manifestations, treatments and prognosis in patients with HLA-B 27-associated uveitis.An HLA B27 associated systemic disorder was present in 10 patients, all of whom were ankylosing spondylitis. Systemic manifestations occurred in 19 patients included oral ulcer in 7 patients, genital ulcer in 3 patients, arthralgia in 16 patients, and skin lesion in 3 patients.Among the total 27 eyes, anterior uveitis was noted in 23 eyes and posterior segment involvement occurred in 4 eyes.The findings of posterior segment involvement included retinal vasulitis in 2 eyes and chorioretinitis in 1 eyes.Severe vitritis occurred in 1 eyes.Most of anterior uveitis was treated with topical steroid eyedrops and periocular steroid injections.In 3 eyes of posterior segment involvement, systemic steroid therapy was required for control of inflammation.After treatment, visual acuity in 23 eyes among 27 eyes was 20/40 or better.And, visual acuity in 4 eyes of posterior segment involvement was 20/25 or better following medical treatment.In conclusion, although HLA-B 27-associated uveitis was mostly related to anterior uveitis, posterior segment manifestations may be occurred in some patients;these patients may require the use of aggressive systemic immunosuppressive therapy to control inflammation and preserve vision.
