Effects and mechanisms of shaoqiduogan on mice with chemical liver injury.
- Author:
Li WU
1
;
Wei WEI
;
Shuang-Ying GUI
;
Wu-Yi SUN
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Antioxidants; isolation & purification; pharmacology; Aspartate Aminotransferases; blood; Astragalus membranaceus; chemistry; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; etiology; metabolism; pathology; Drug Combinations; Glucosides; isolation & purification; pharmacology; Glutathione Peroxidase; metabolism; Liver; metabolism; pathology; Male; Malondialdehyde; metabolism; Mice; Paeonia; chemistry; Plants, Medicinal; chemistry; Protective Agents; isolation & purification; pharmacology; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2006;31(21):1807-1810
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effects and mechanisms of SQDG on carbon tetrachloride-induced chemical liver injury in mice as well as its possible mechanisms. At the same time the pharmacodynamics of SQDG was compared with TGP or ASTs of effective dose.
METHODThe model of carbon tetrachloride-induced chemical liver injury in mice was prepared. The levels of ALT, AST, MDA content, SOD and GSH-Px activities in liver homogenate were assayed by spectrophotometry; Meanwhile, hepatic pathological examination was observed.
RESULTProtective effect of SQDG on carbon tetrachloride-induced chemical liver injury: SQDG was able to significantly decrease serum transaminase levels of chemical liver injury's mice induced by carbon tetrachloride, decreased MDA content and improved the reduced SOD and GSH-px levels in liver homogenate. Furthermore, SQDG also attenuate the area and extent of necrosis and reduce the infiltration of inflammatory cell. Compared with TGP or ASTs of effective dose, SQDG has a better effect on carbon tetrachloride-induced chemical liver injury in mice.
CONCLUSIONSQDG can protect mice injured by carbon tetrachloride-induced chemical.
