Analysis of association between the IRF5 gene single nucleotide polymorphism and allergic rhinitis

VernacularTitle:干扰素调节因子5的单核苷酸多态性与变应性鼻炎的相关性研究
Author: Hui-Jie FENG ¹ ; Wen-Xiu LI ; Su-Juan BAI ; De-Yun WANG
Author Information

1. 200060,上海市普陀区人民医院耳鼻咽喉科
Keywords: Interferon regulatory factors; Polymorphism,single nucleotide; Rhinitis,allergic,perennial
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2013;48(1):22-25
CountryChina
Language:Chinese
Abstract: Objective To study the possible association between interferon regulatory factor 5 (IRF5) gene polymorphism and allergic rhinitis (AR).Methods Six independent single nucleotide polymorphism (SNP,rs729302,rs4728142,rs3807306,rs2070197,rs11770589,rs2280714) were analyzed.The genotype and allele frequencies were detected in 110 AR patients and 101 healthy controls in Singapore Chinese population by polymerase chain reaction (PCR) and restriction fragment length polymorphism(RFLP).Results Rs729302 was rejected as it was not polymorphic.For others SNP,no statistically significant difference was detected in genotype between AR and healthy control group (x2 value were 0.21,5.02,0.01,2.91,0.37,all P ＞ 0.05).No statistically significant difference was detected in allele frequencies between AR and healthy control group (x2 value were 0.00,2.78,0.01,2.31,0.00,all P ＞ 0.05).Conclusion No association is observed between IRF5 and AR in Singapore Chinese population.