Olfactory bulb volume and depth of olfactory sulcus in patients with idiopathic olfactory loss
10.3760/cma.j.issn.1673-0860.2013.04.004
- VernacularTitle:特发性嗅觉减退患者嗅球体积与嗅沟深度的研究
- Author:
Jin-Ling ZHANG
1
;
Wei HANG
;
Gang LIU
Author Information
1. 300060,天津市环湖医院耳鼻咽喉科
- Keywords:
Olfaction disorders;
Olfactory bulb;
Olfactory pathways;
Megnetic resonance imaging
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2013;48(4):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between olfactory bulb (OB) volume with depth of olfactory sulcus(OS) and olfactory function in patients with idiopathic olfactory loss(IOL).Methods Forty patients with IOL and forty normal controls were compared in terms of olfactory function T&T testing and magnetic resonance imaging (MRI,observation of OB volume and depth of OS).T&T testing and MRI were performed again after a year in 40 IOL patients,the results were compared with the first time.Results OB volume of left side in IOL patients was (30.31 ±4.07) mm3,right side was (30.82 ±4.14) mm3,average OB volume was (30.53 ±4.10)mm3 ; OB volume of left side in normal controls was (49.56 ±7.19)mm3,right side was (49.84 ±7.25)mm3,average OB volume was (49.73 ±7.21)mm3.OB volume was lower in IOL patients as compared to controls(t value were 8.122,8.274,8.231,all P ＜ 0.01).OS depth study revealed no statistical different between IOL patients and controls(t value were 0.998,1.017,1.001,all P ＞ 0.05).Olfactory discriminate threshold was negatively correlated with OB volume in IOL patients (r =-0.53,P ＜ 0.05).There was no correlation with the depth of OS(r =-0.19,P ＞ 0.05).Among 40 IOL patients,when followed-up,12 showed increased in OB volume and olfactory function after a year,but no statistical difference was found with the first time (t value were 0.831,0.864,0.826,all P ＞ 0.05).The other 28 patients showed no significant changes of OB volume and olfactory function.Conclusions The OB volume was lower in IOL patients as compared to normal controls.The depth of OS showed no significant changes in IOL patients.The OB volume was correlated with olfactory function.The depth of OS did not correlated with the olfactory function.Some IOL patients showed increased OB volume and improved olfactory function with the development of the disease.
