Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like dermatitis induced by trichloroethylene.
- Author:
Xin-yun XU
1
;
Guan-hao CHEN
;
Nan WU
;
Lei YU
;
Fang HUANG
;
Lin-qing YANG
Author Information
- Publication Type:Journal Article
- MeSH: Cytochrome P-450 CYP1A1; genetics; Cytochrome P-450 CYP2E1; genetics; Dermatitis, Occupational; genetics; Genetic Predisposition to Disease; Humans; Interleukin-4; genetics; Polymorphism, Single Nucleotide; Trichloroethylene; adverse effects
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(2):71-73
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and susceptibility of medicamentosa-like dermatitis induced by trichloroethylene (TCE).
METHODS35 patients with medicamentosa-like dermatitis induced by TCE were chosen as the patient group, and 35 healthy workers as control group. The real-time quantitative polymerase chain reaction (PCR) with TaqMan minor groove binding (MGB) probes was used to test single nucleotide polymorphisms (SNP) of CYP2E1, CYP1A1 and IL-4 in the patients with medicamentosa-like dermatitis as well as in the control. The genotypes and the frequency of genotype or allele were compared between the patients and control with statistical analysis.
RESULTSThe frequency of allele G within CYP1A1 gene (rs1048943) was significantly higher in TCE patients (37.1%) than that in control (P<0.05); the frequency of allele T within CYP2E1-1053 C/T was significantly higher in TCE patients (41.4%) than that in control (P<0.01); the frequency of T/T within IL-4-588 C/T (rs2243250) was significantly higher in TCE patients (75.0%) than that in control (P<0.01), and the frequency of allele T within IL-4-588 C/T (rs2243250) was also significantly higher in TCE patients (87.5%) than that in control (P<0.01).
CONCLUSIONThe gene polymorphism of CYP2E1, CYP1A1, IL-4 is probably associated with hypersensitivity for the TCE patients with medicamentosa-like dermatitis, and could be one of the genetic factors related to the individual susceptibility to TCE exposure.
