Application of multi-coeffieient of variation significance test for toxicology study.
- Author:
Sheng-lian LI
1
;
Sheng-kui TAN
;
Wen-xiang SHI
;
Chao-yan OU
;
Ming-shen LU
;
Ya-dan ZHENG
;
Hua LUO
;
Xin-zhen QU
;
Cai-xia GUO
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Disease Models, Animal; Female; Lead Poisoning; enzymology; Rats; Rats, Wistar; Statistical Distributions
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(2):74-76
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish the methods of calculating and analyzing the multi-coefficient of variation significance test for the toxicology study.
METHODSThe paper aimed to confirm the significance level with the method of Bonferroni and then compared the methods of calculating and analyzing of the experiment groups with the control group respectively.
RESULTSThe significance level of multi-coefficient of variation significance test was confirmed as alpha1=0.0167. Compared with the control groups, the activity of ALT in serum both in 30 mg/kg and 60 mg/kg groups did not change in the average significance test, which was not statistically significant (P>0.05), while it changed in the variation significance test, which was of statistical significance (P<0.0167). The activity of AST in serum in 60 mg/kg group did not change in the average significance test (P>0.05), while it changed in the variation significance test (P<0.0167).
CONCLUSIONThe complete changes of the indexes can only be shown by use of both the average significance test and the variation significance test together.
